التفاصيل البيبلوغرافية
| العنوان: |
New Biocides Based on N 4 -Alkylcytidines: Effects on Microorganisms and Application for the Protection of Cultural Heritage Objects of Painting. |
| المؤلفون: |
Alexandrova, Liudmila A., Oskolsky, Ivan A., Makarov, Dmitry A., Jasko, Maxim V., Karpenko, Inna L., Efremenkova, Olga V., Vasilyeva, Byazilya F., Avdanina, Darya A., Ermolyuk, Anna A., Benko, Elizaveta E., Kalinin, Stanislav G., Kolganova, Tat'yana V., Berzina, Maria Ya., Konstantinova, Irina D., Chizhov, Alexander O., Kochetkov, Sergey N., Zhgun, Alexander A. |
| المصدر: |
International Journal of Molecular Sciences; Mar2024, Vol. 25 Issue 5, p3053, 20p |
| مصطلحات موضوعية: |
CULTURAL property, BIOCIDES, NUCLEOSIDE derivatives, DRUG resistance in microorganisms, PROTECTION of cultural property, BENZALKONIUM chloride, MYCOBACTERIUM smegmatis, MOLDS (Fungi), GRAM-positive bacteria |
| مصطلحات جغرافية: |
MOSCOW (Russia), RUSSIA |
| مستخلص: |
The rapid increase in the antibiotic resistance of microorganisms, capable of causing diseases in humans as destroying cultural heritage sites, is a great challenge for modern science. In this regard, it is necessary to develop fundamentally novel and highly active compounds. In this study, a series of N4-alkylcytidines, including 5- and 6-methylcytidine derivatives, with extended alkyl substituents, were obtained in order to develop a new generation of antibacterial and antifungal biocides based on nucleoside derivatives. It has been shown that N4-alkyl 5- or 6-methylcytidines effectively inhibit the growth of molds, isolated from the paintings in the halls of the Ancient Russian Paintings of the State Tretyakov Gallery, Russia, Moscow. The novel compounds showed activity similar to antiseptics commonly used to protect works of art, such as benzalkonium chloride, to which a number of microorganisms have acquired resistance. It was also shown that the activity of N4-alkylcytidines is comparable to that of some antibiotics used in medicine to fight Gram-positive bacteria, including resistant strains of Staphylococcus aureus and Mycobacterium smegmatis. N4-dodecyl-5- and 6-methylcytidines turned out to be the best. This compound seems promising for expanding the palette of antiseptics used in painting, since quite often the destruction of painting materials is caused by joint fungi and bacteria infection. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder