التفاصيل البيبلوغرافية
| العنوان: |
Insulin receptor substrate 2 gene Gly1057Asp polymorphism is a risk factor for nonalcoholic fatty liver disease. |
| المؤلفون: |
Nouri, Shadi, Mahmoudi, Touraj, Hojjati, Farzaneh, Najafabadi, Zeinab Nourmohammadi, Shafiee, Radmehr, Sayedsalehi, Shiva, Dehghanitafti, Atefeh, Ardalani, Abbas, Kohansal, Kiarash, Rezamand, Gholamreza, Asadi, Asadollah, Nobakht, Hossein, Dabiri, Reza, Farahani, Hamid, Tabaeian, Seidamir Pasha, Zali, Mohammad Reza |
| المصدر: |
Laboratory Medicine; Mar2024, Vol. 55 Issue 2, p215-219, 5p |
| مصطلحات موضوعية: |
GENETICS of disease susceptibility, NON-alcoholic fatty liver disease, RISK assessment, CARRIER proteins, RESEARCH funding, T-test (Statistics), POLYMERASE chain reaction, CHI-squared test, DESCRIPTIVE statistics, GENETIC polymorphisms, RESEARCH, DATA analysis software, CONFIDENCE intervals, SINGLE nucleotide polymorphisms, DISEASE risk factors |
| مستخلص: |
Objective Nonalcoholic fatty liver disease (NAFLD), which is an emerging global chronic liver disease, has a close association with insulin resistance. We aimed to determine whether the Gly1057Asp (rs1805097) polymorphism of the insulin receptor substrate 2 (IRS2) gene is associated with NAFLD. Methods Using the polymerase chain reaction-restriction fragment length polymorphism method, 135 patients with biopsy-proven NAFLD and 135 controls underwent IRS2 genotype analysis. Results Genotype and allele distributions of the IRS2 gene Gly1057Asp variant conformed to the Hardy-Weinberg equilibrium in both the case and control groups (P >.05). The Asp/Asp genotype of IRS2 gene Gly1057Asp polymorphism compared with Gly/Gly genotype was associated with a 2.1-fold increased risk for NAFLD after adjustment for confounding factors (P =.029; odds ratio = 2.10, 95% CI = 1.23-3.97). Conclusion Our findings revealed for the first time that the Gly1057Asp Asp/Asp genotype of the IRS2 gene is a marker of increased NAFLD susceptibility; however, studies in other populations are required to confirm the results. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
