التفاصيل البيبلوغرافية
| العنوان: |
The contribution of BvgR, RisA, and RisS to global gene regulation, intracellular cyclic-diGMP levels, motility, and biofilm formation in Bordetella bronchiseptica. |
| المؤلفون: |
Nicholson, Tracy L., Waack, Ursula, Fleming, Damarius S., Qing Chen, Miller, Laura C., Merkel, Tod J., Stibitz, Scott |
| المصدر: |
Frontiers in Microbiology; 2024, p1-21, 21p |
| مصطلحات موضوعية: |
GENETIC regulation, NUCLEOTIDE sequencing, BIOFILMS |
| مستخلص: |
Bordetella bronchiseptica is a highly contagious respiratory bacterial veterinary pathogen. In this study the contribution of the transcriptional regulators BvgR, RisA, RisS, and the phosphorylation of RisA to global gene regulation, intracellular cyclic-di-GMP levels, motility, and biofilm formation were evaluated. Next Generation Sequencing (RNASeq) was used to differentiate the global gene regulation of both virulence-activated and virulence-repressed genes by each of these factors. The BvgAS system, along with BvgR, RisA, and the phosphorylation of RisA served in cyclic-di-GMP degradation. BvgR and unphosphorylated RisA were found to temporally regulate motility. Additionally, BvgR, RisA, and RisS were found to be required for biofilm formation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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