التفاصيل البيبلوغرافية
| العنوان: |
Safety Assessment: a Comparative Analysis of Quantitative Content of Bacterial Endotoxins and Evaluation of Pyrogenicity of the Kazakhstan Vaccine QazCovid-in® against COVID-19. |
| المؤلفون: |
Jekebekov, K. K., Nurpeisova, A. S., Abay, Zh.S., Shorayeva, K. A., Absatova, Zh.S., Abitayev, R. T., Kalimolda, E. Zh., Moldagulova, S. U., Assanzhanova, N. N., Omurtay, A. D., Shayakhmetov, Ye.A., Sadikaliyeva, S. O., Barakbayev, K. B., Kassenov, M. M., Zakarya, K. D., Abduraimov, Ye.O. |
| المصدر: |
Bulletin of Experimental Biology & Medicine; Feb2024, Vol. 176 Issue 4, p452-456, 5p |
| مصطلحات موضوعية: |
ENDOTOXINS, ALUMINUM hydroxide, COMPARATIVE studies, INTRAVENOUS injections, CONTENT analysis, COVID-19 |
| مصطلحات جغرافية: |
KAZAKHSTAN |
| مستخلص: |
We measured the levels of bacterial endotoxins in the bulk vaccine product (BVP) and finished vaccine QazCovid-in® and evaluated the effect of aluminum hydroxide (adjuvant) on the results of LAL test and pyrogenicity of samples in vivo (in rabbits receiving intravenous injection into the marginal ear vein). Administration of BVP with LPS resulted in a dose-dependent increase in body temperature in rabbits similar to that caused by LPS alone, which suggests that aluminum hydroxide in the vaccine did not affect the pyrogenic response in rabbits. Moreover, the LAL test showed that the aluminum hydroxide did not hinder LPS activity after serial dilution of samples. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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