التفاصيل البيبلوغرافية
| العنوان: |
The Evolving Landscape of Gout in the Female: A Narrative Review. |
| المؤلفون: |
Lee, Jennifer, Sumpter, Nicholas, Merriman, Tony R., Liu-Bryan, Ru, Terkeltaub, Robert |
| المصدر: |
Gout, Urate, & Crystal Deposition Disease; Mar2024, Vol. 2 Issue 1, p1-16, 16p |
| مصطلحات موضوعية: |
GOUT, CHRONIC kidney failure, BODY mass index, GENETIC polymorphisms, DISEASE prevalence, NON-communicable diseases |
| مستخلص: |
Gout is at least three times more prevalent in males than in females. However, concurrent with rising total gout prevalence, complex factors, including comorbidities, diet, lifestyle, and aging, have promoted higher gout prevalence in females. This narrative review focuses on summarizing recent developments in the landscape of gout in females and the mechanisms involved. New knowledge on sex hormone effects on both urate-excreting and urate-reabsorbing transporters and higher hypertension and chronic kidney disease prevalence in females compared to males may help explain why gout incidence rises robustly after menopause in females, to approach that in males. Racial and ethnic factors, risk profiles based on heritable genetic polymorphisms of urate transporters, diet, body mass index, and lifestyle factors differ according to sex. In addition, sex differences in clinical phenotypes, outcomes of gout, and non-gout illnesses include more frequent comorbidities, more pain and disability during gout flares, different perceptions of disease burden, and more frequent severe cutaneous hypersensitivity reaction to allopurinol in females. Collectively, such findings support the potential clinical benefits of tailoring gout and hyperuricemia treatment according to sex. [ABSTRACT FROM AUTHOR] |
|
Copyright of Gout, Urate, & Crystal Deposition Disease is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
