التفاصيل البيبلوغرافية
| العنوان: |
Novel Study of SARS-CoV-2 RNA in Post-Reperfusion Liver Biopsies after Transplantation Using COVID-19-Positive Donor Allografts. |
| المؤلفون: |
Whitrock, Jenna N., Carter, Michela M., Price, Adam D., Delman, Aaron M., Pratt, Catherine G., Wang, Jiang, Sharma, Divya, Quillin III, Ralph C., Shah, Shimul A. |
| المصدر: |
Transplantology; Mar2024, Vol. 5 Issue 1, p46-50, 5p |
| مصطلحات موضوعية: |
RESPIRATORY disease risk factors, RNA analysis, NASOPHARYNX microbiology, MORTALITY risk factors, BIOPSY, MEDICAL protocols, KIDNEY transplantation, RISK assessment, BILIOUS diseases & biliousness, ACADEMIC medical centers, HOMOGRAFTS, REVERSE transcriptase polymerase chain reaction, COVID-19 vaccines, RETROSPECTIVE studies, CAUSES of death, ORGAN donation, SURGICAL therapeutics, DESCRIPTIVE statistics, SURGICAL complications, LONGITUDINAL method, BRONCHOALVEOLAR lavage, LIVER diseases, GRAFT rejection, REPERFUSION, LIVER, INFECTIOUS disease transmission, ADVERSE health care events, POSTOPERATIVE period, SARS-CoV-2, MICROBIAL genetics, LIVER transplantation, COVID-19, VASCULAR diseases, HYPOXEMIA, DISEASE risk factors |
| مصطلحات جغرافية: |
OHIO |
| مستخلص: |
The utilization of COVID-19-positive donors has expanded the donor pool for transplantation since the initiation of COVID allograft utilization protocols. However, the biopsy-proven PCR transmission rate of COVID-19 from these allografts has not been well documented. In August 2021, an institutional COVID-19-positive allograft protocol was implemented for liver and kidney transplants. Post-reperfusion liver biopsies were obtained intra-operatively to evaluate for COVID-19 RNA, and post-operative day 7 nasopharyngeal reverse transcriptase polymerase chain reaction (RT-PCR) swabs were collected. The primary endpoints evaluated included COVID-19 RNA on biopsy and COVID-19 detected via nasopharyngeal RT-PCR swab on post-operative day 7. A total of 20 vaccinated recipients underwent transplantation (17 liver only, 3 simultaneous liver and kidney) with whole liver allografts from 20 COVID-19-positive deceased donors between August 2021 and April 2022. 95% (19/20) of donors were asymptomatic at the time of donation. On post-reperfusion liver allograft biopsies, COVID-19 RNA was found in 10% (2/20) of the samples. All the recipients were COVID-19-negative on post-operative day 7 nasopharyngeal RT-PCR, showing a 0% transmission rate of COVID-19 from the positive allografts. The use of COVID-19 allografts appears to be a safe practice, with no PCR-detectable transmission of COVID-19 despite 10% of the liver allografts having COVID-19 RNA present on post-reperfusion biopsy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
