التفاصيل البيبلوغرافية
| العنوان: |
Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction. |
| المؤلفون: |
Puigdellívol Grifell, Jordi, Comellas Berenguer, Carme, Steinbacher, Gilbert, Kranjcec, Tomislav, Álvarez Díaz, Pedro, López Pujol, Antoni, Acosta Pereira, Asunción, Sánchez Martos, Maximiliano, Fernández Velázquez, José Reyes, Esparza Pagán, Miguel Ángel, Lainez Romo, Víctor, Payán Martín, Luis, Giménez Gonzalo, Jordi, Carreras Vidal, Christian, Sulbarán, José David, Oliveras Riera, Jaume |
| المصدر: |
Journal of Dietary Supplements; 2024, Vol. 21 Issue 3, p374-388, 15p |
| مصطلحات موضوعية: |
INTEGRATIVE medicine, SCIENTIFIC observation, VISUAL analog scale, FUNCTIONAL assessment, TREATMENT effectiveness, DESCRIPTIVE statistics, CHONDROITIN sulfates, OSTEOARTHRITIS, PAIN, GLUCOSAMINE, QUALITY of life, RESEARCH, COLLAGEN, HEALTH outcome assessment, DIETARY supplements, WELL-being |
| مستخلص: |
Osteoarthritis (OA) is an age-related degenerative joint disease with a great impact on patients' well-being and quality of life. This is an observational, open, single-arm multicenter study aimed to evaluate the effectiveness of a nutritional supplement in patients with knee and/or hip OA. A total of 186 patients were recruited from Spanish centers and received a supplement containing hydrolyzed collagen (3000 mg), chondroitin sulfate (800 mg), glucosamine sulfate (700 mg), turmeric extract (250 mg) and devil's claw (150 mg), once daily during 6 months. The primary outcome was the patients' self-perceived pain in the affected joints measured with a visual analogue scale (VAS). Secondary outcome was the patient's functioning, measured with the Lequesne Functional Index and the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Participants showed a significant reduction in self-perceived pain after 3 (mean reduction ± standard deviation, 1.99 ± 1.05) and 6 months (3.57 ± 1.39) of treatment (p < 0.0001 in both comparisons). Lequesne Functional Index score was significantly reduced at 3 months (3.86 ± 2.94) and at 6 months (6.73 ± 4.30) of treatment (p < 0.0001 in both comparisons). The WOMAC index was also significantly reduced after 3 (14.24 ± 10.04) and 6 months (26.43 ± 17.35) of treatment (p < 0.0001 in both comparisons). Significant reductions in WOMAC subdomains (p < 0.0001 in all comparisons) were observed. No severe adverse events were reported during the study. The main results arising from this study show that this nutritional supplementation can improve OA-related symptoms and physical function with a good safety profile in patients with hip and/or knee OA. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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