التفاصيل البيبلوغرافية
| العنوان: |
New Antimicrobial Accramycins from Streptomyces sp. MA37 Variant. |
| المؤلفون: |
Alabed, Aziz, Kyeremeh, Kwaku, Deng, Hai |
| المصدر: |
Molbank; Mar2024, Vol. 2024 Issue 1, pM1754, 8p |
| مصطلحات موضوعية: |
STREPTOMYCES, NUCLEAR magnetic resonance, KLEBSIELLA pneumoniae, STAPHYLOCOCCUS aureus, MASS spectrometry, ENTEROBACTER cloacae |
| مستخلص: |
In our continued desire to isolate more bioactive compounds from the Streptomyces sp. MA37 variant, ΔaccJ, three new accramycin derivatives have been successfully characterised. The structures of accramycin L-N (1–3) were established by high-resolution mass spectrometry and 1D and 2D nuclear magnetic resonance. The antimicrobial evaluation of accramycin L-N against Staphylococcus aureus, Klebsiella pneumoniae, and Enterobacter cloacae showed minimum inhibitory concentration (MIC) values ranging from 0.77 to 13.02 µg/mL. Accramycin L exhibited the most significant activity against S. aureus. In addition, accramycin L-N (1–3) displayed significant activity against K. pneumoniae at the MIC values of 0.81, 0.77, and 0.79 µg/mL, respectively. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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