التفاصيل البيبلوغرافية
| العنوان: |
اثر حفاظتی سداب بر انفارکتوس میوکارد ناشی از ایزوپروترنول در موش بزرگ آزمایشگاهی. (Persian) |
| Alternate Title: |
Protective effect of Ruta graveolens on myocardial infarction induced by isoprenaline in rats. (English) |
| المؤلفون: |
فریبا هوشمند ، زه, لری گوئینی, سمیه نجفی چالشتر |
| المصدر: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p657-657, 2p |
| مصطلحات موضوعية: |
COMMON rue, MYOCARDIAL infarction, CELL death, ISOPROTERENOL, DEHYDROGENASES |
| مستخلص: |
Introduction: Myocardial infarction caused by ischemia is the most common cause of death among cardiovascular disorders. Ruta graveolens (Ruta) is a medicinal plant that is used in traditional medicine to treat various diseases. Therefore, the aim of the present study was to investigate the cardioprotective effects of Ruta hydroalcoholic extract against isoproterenol (ISO)-induced myocardial infarction (MI) in male rats. Methods and Materials: In this study, male rats were randomly divided into five groups, namely control, ISO, and Ruta+ISO groups. Treatment groups received different doses of Ruta (5, 10, 20 mg/kg, i.p.) for 15 days. MI was induced by injection of isoproterenol (100 mg/kg, s.c.) at days 14 and 15. On 16th day, the rats were anaesthetized and electrocardiogram parameters were recorded. Then blood samples were obtained for biochemical assay and the hearts were removed to measure the heart to body weight ratio and Infarct size evaluation. Infarct size in the ischemic area was calculated by staining with TTC. Results: Isoproterenol administration showed changes in ECG pattern, including ST-segment elevation (diagnostic of myocardial infarction), increase in the serum levels of cardiac injury markers (creatine kinase-MB, lactate dehydrogenase), decreased total antioxidant capacity (FRAP) and altered lipid peroxidation (MDA) in the serum and heart. Isoproterenol administration also increased infarct size. Ruta pretreatment dose dependently protected all the parameters of ISO-induced myocardial infarction in rats. Conclusion: This study showed that Ruta graveolens extract with its antioxidant properties protects the heart from ischemic damage caused by isoproterenol and could be a promising cardioprotective agent for future applications in patients with MI. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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