التفاصيل البيبلوغرافية
| العنوان: |
،BBB اثرات تجویز داخل بینی رسوراترول بر عملکرد عصبی رفتاری، یکپارچگی اِدِم و حجم انفارکتوس مغز در مدل موش بزرگ آزمایشگاهی ایسکمی مغزی. (Persian) |
| المؤلفون: |
فرزانه کریمی, مریم اوج فرد |
| المصدر: |
Koomesh: Journal of Semnan University of Medical Sciences; Sep/Oct2023, Vol. 25 Issue 5, p30-30, 2p |
| مصطلحات موضوعية: |
ISCHEMIC stroke, RESVERATROL, NEUROBEHAVIORAL disorders, CEREBRAL edema, CELL death |
| مستخلص: |
Introduction: Ischemic stroke (IS) generally occurs when a vessel in the brain becomes blocked by thrombi or emboli, reducing the supply of oxygen and blood to the brain. Resveratrol (3,4,5-trihydroxystilbene) is a phenolic compound with anti-apoptosis, anti-inflammatory, and antioxidant activities. This study used the middle cerebral artery occlusion (MCAO) model to investigate the effects of resveratrol intranasal treatment on brain ischemia. Methods and Materials: Fifty-four male rats were divided into three groups: the sham-operated group, which was exposed to only surgical stress; the vehicle and resveratrol groups, which received intranasal vehicle or 50 mg/kg resveratrol for 7 days following MCAO. The modified neurologic severity scores at 2 hours, 72 hours, and 7 days after MCAO were examined. Evans blue extravasation was applied to assess blood brain barrier (BBB) disruption. Infarct volume was also measured in addition to the brain water content measurement. Results: Intranasal treatment with resveratrol for 7 days after brain ischemia improved neurobehavioral function, BBB disruption, cerebral edema, and infarct volume. Conclusion: Intranasal administration of resveratrol can be an alternative treatment method for ischemic stroke. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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