التفاصيل البيبلوغرافية
| العنوان: |
Anti-survival motor neuron complex antibodies as a novel biomarker for pulmonary arterial hypertension and interstitial lung disease in mixed connective tissue disease. |
| المؤلفون: |
Todoroki, Yasuyuki, Satoh, Minoru, Kubo, Satoshi, Kosaka, Shunpei, Fukuyo, Shunsuke, Nakatsuka, Keisuke, Saito, Kazuyoshi, Tanaka, Shin, Nakayamada, Shingo, Tanaka, Yoshiya |
| المصدر: |
Rheumatology; Apr2024, Vol. 63 Issue 4, p1068-1075, 8p |
| مصطلحات موضوعية: |
RESEARCH funding, MYOSITIS, AUTOANTIBODIES, MOTOR neurons, SCIENTIFIC observation, INTERSTITIAL lung diseases, SYSTEMIC lupus erythematosus, SYMPTOMS, DESCRIPTIVE statistics, CONNECTIVE tissue diseases, SYSTEMIC scleroderma, RESEARCH, PULMONARY arterial hypertension, BIOMARKERS, PRECIPITIN tests, DISEASE complications |
| مصطلحات جغرافية: |
JAPAN |
| مستخلص: |
Objective The presence of anti-U1 RNP antibodies (Abs) is critical for diagnosing MCTD. The aim of this study is to evaluate the clinical relevance of anti-survival motor neuron (SMN) complex Abs, which often coexist with anti-U1 RNP Abs. Methods A total of 158 newly diagnosed consecutive cases of SLE, SSc or MCTD with anti-U1 RNP Abs were enrolled in this multicentre observational study between April 2014 and August 2022. Serum anti-SMN complex Abs were screened by immunoprecipitation of 35S-methionine-labelled cell extracts, and associations between anti-SMN complex Abs positivity and clinical characteristics were analysed. Results Anti-SMN complex Abs were detected in 36% of MCTD patients, which was significantly higher than that in SLE (8%) or SSc (12%). Among MCTD patients classified based on the combination of the clinical features of SLE, SSc and idiopathic inflammatory myopathies, anti-SMN complex Abs showed the highest prevalence in a subset with clinical features of all three components. Anti-SMN complex Abs–positive MCTD had a higher prevalence of pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD), which are related to poor prognosis, than negative patients. Moreover, all three cases of death within 1 year of the treatment were positive for anti-SMN complex Abs. Conclusions Anti-SMN complex Abs is the first biomarker of a typical subset of MCTD which bears organ damages such as PAH and ILD. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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