التفاصيل البيبلوغرافية
| العنوان: |
Developmental self-reactivity determines pathogenic Tc17 differentiation potential of naive CD8+ T cells in murine models of inflammation. |
| المؤلفون: |
Lee, Gil-Woo, Kim, Young Ju, Lee, Sung-Woo, Kim, Hee-Ok, Kim, Daeun, Kim, Jiyoung, Kim, You-Me, Kang, Keunsoo, Rhee, Joon Haeng, Chung, Ik Joo, Bae, Woo Kyun, Oh, In-Jae, Yang, Deok Hwan, Cho, Jae-Ho |
| المصدر: |
Nature Communications; 4/4/2024, Vol. 15 Issue 1, p1-16, 16p |
| مصطلحات موضوعية: |
T cells, T cell differentiation, INFLAMMATORY bowel diseases, CELL populations, GRAFT versus host disease, CELL differentiation |
| مستخلص: |
The differentiation of naive CD8+ T cells into effector cells is important for establishing immunity. However, the effect of heterogeneous naive CD8+ T cell populations is not fully understood. Here, we demonstrate that steady-state naive CD8+ T cells are composed of functionally heterogeneous subpopulations that differ in their ability to differentiate into type 17 cytotoxic effector cells (Tc17) in a context of murine inflammatory disease models, such as inflammatory bowel disease and graft-versus-host disease. The differential ability of Tc17 differentiation is not related to T-cell receptor (TCR) diversity and antigen specificity but is inversely correlated with self-reactivity acquired during development. Mechanistically, this phenomenon is linked to differential levels of intrinsic TCR sensitivity and basal Suppressor of Mothers Against Decapentaplegic 3 (SMAD3) expression, generating a wide spectrum of Tc17 differentiation potential within naive CD8+ T cell populations. These findings suggest that developmental self-reactivity can determine the fate of naive CD8+ T cells to generate functionally distinct effector populations and achieve immense diversity and complexity in antigen-specific T-cell immune responses. The heterogeneity in naive CD8+ T cells is essential for diverse immune responses. Here the authors show that variations in developmental self-reactivity of CD8+ T cells influence their differentiation into Tc17 cells in inflammatory conditions. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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