التفاصيل البيبلوغرافية
| العنوان: |
Identification and characterization of nuclear localization signals in the circumsporozoite protein of Plasmodium falciparum. |
| المؤلفون: |
Shrikondawar, Akshaykumar Nanaji, Chennoju, Kiranmai, Ghosh, Debasish Kumar, Ranjan, Akash |
| المصدر: |
FEBS Letters; Apr2024, Vol. 598 Issue 7, p801-817, 17p |
| مصطلحات موضوعية: |
CIRCUMSPOROZOITE protein, PLASMODIUM falciparum, CELL nuclei, ASPARAGINE, ARGININE |
| مستخلص: |
Secretory proteins of Plasmodium exhibit differential spatial and functional activity within the host cell nucleus. However, the nuclear localization signals (NLSs) for these proteins remain largely uncharacterized. In this study, we have identified and characterized two NLSs in the circumsporozoite protein of Plasmodium falciparum (Pf‐CSP). Both NLSs in the Pf‐CSP contain clusters of lysine and arginine residues essential for specific interactions with the conserved tryptophan and asparagine residues of importin‐α, facilitating nuclear translocation of Pf‐CSP. While the two NLSs of Pf‐CSP function independently and are both crucial for nuclear localization, a single NLS of Pf‐CSP leads to weak nuclear localization. These findings shed light on the mechanism of nuclear penetrability of secretory proteins of Plasmodium proteins. [ABSTRACT FROM AUTHOR] |
|
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder