التفاصيل البيبلوغرافية
| العنوان: |
Association between mtDNA haplogroups and skeletal fluorosis in Han population residing in drinking water endemic fluorosis area of northern China. |
| المؤلفون: |
Ji, Yi, Guo, Ning, Lu, Chunqing, Zhang, Meichen, Wang, Sa, Yang, Liu, Li, Qiao, Lv, Man, Yang, Yanmei, Gao, Yanhui |
| المصدر: |
International Journal of Environmental Health Research; May2024, Vol. 34 Issue 5, p2397-2406, 10p |
| مصطلحات موضوعية: |
RISK assessment, ENVIRONMENTAL health, PHYSICAL diagnosis, FLUORIDES, PHYLOGENY, RESEARCH funding, SKELETON, BONE diseases, BLOOD collection, LOGISTIC regression analysis, KRUSKAL-Wallis Test, CHI-squared test, HAPLOGROUPS, WATER supply, CASE-control method, URINE collection & preservation, CONFIDENCE intervals, DATA analysis software, COMPARATIVE studies, GENETIC mutation, MITOCHONDRIAL DNA, SINGLE nucleotide polymorphisms, SEQUENCE analysis, GENOMES, DISEASE risk factors |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
To investigate the association between mtDNA genetic information and the risk of SF, individuals were conducted in the drinking water endemic fluorosis area in northern China, sequenced the whole genome of mtDNA, identified the SNPs and SNVs, analyzed the haplogroups, and diagnosed SF, and then, the effect of mtDNA genetic information on the risk of SF was evaluated. We find that, D5 haplogroup and its specific SNPs reduced the risk, while the D4 haplogroup and its specific SNPs increased the risk of SF. The number of SNVs in coding regions of mitochondrial respiratory chain (MRC) is different between the controls and cases. This suggests that D5 haplogroup may play a protective role in the risk of SF, while the opposite is observed for the D4 haplogroup, this may relate to their specific SNPs. And SNVs that encode the MRC complex may also be associated with the risk of SF. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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