التفاصيل البيبلوغرافية
| العنوان: |
Potent nitric oxide inhibitory sesquiterpenoids from the rhizome of Curcuma aromatica Salisb. |
| المؤلفون: |
Pabuprapap, Wachirachai, Chaichompoo, Waraluck, Chulrik, Wanatsanan, Chunglok, Warangkana, Thothaisong, Teerawut, Denlumpai, Panida, Namdaung, Umalee, Suksamrarn, Apichart |
| المصدر: |
Natural Product Research; May2024, Vol. 38 Issue 10, p1739-1747, 9p |
| مصطلحات موضوعية: |
CURCUMA, NITRIC oxide, SESQUITERPENES, AMINOGUANIDINE, ZINGIBERACEAE |
| مستخلص: |
One new sesquiterpenoid, curcaromatin (1), together with twenty-one known compounds 2–22, were isolated from the rhizomes of Curcuma aromatica Salisb. (Zingiberaceae). Their structures were established by extensive spectroscopic (1D and 2D NMR and HR-MS) analysis. Most of the isolated compounds were investigated for nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 cells. (−)-Xanthorrhizol (3) displayed the strongest NO inhibitory activity with an IC50 value of 4.3 μM, which was 3.7-fold more active than the reference compound, aminoguanidine (IC50 15.9 μM). The selectivity index (SI > 28.1) of compound 3 was almost 3-fold higher than that of aminoguanidine. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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