التفاصيل البيبلوغرافية
| العنوان: |
High frequencies of alpha common cold coronavirus/SARSCoV-2 cross-reactive functional CD4+ and CD8+ memory T cells are associated with protection from symptomatic and fatal SARS-CoV-2 infections in unvaccinated COVID-19 patients. |
| المؤلفون: |
Coulon, Pierre-Gregoire, Prakash, Swayam, Dhanushkodi, Nisha R., Srivastava, Ruchi, Zayou, Latifa, Tifrea, Delia F., Edwards, Robert A., Figueroa, Cesar J., Schubl, Sebastian D., Hsieh, Lanny, Nesburn, Anthony B., Kuppermann, Baruch D., Bahraoui, Elmostafa, Vahed, Hawa, Gil, Daniel, Jones, Trevor M., Ulmer, Jeffrey B., BenMohamed, Lbachir |
| المصدر: |
Frontiers in Immunology; 2024, p1-26, 26p |
| مصطلحات موضوعية: |
COVID-19, COMMON cold, IMMUNOLOGIC memory, SARS-CoV-2, T cells, WORD frequency, MENTAL foramen |
| مستخلص: |
Background: Cross-reactive SARS-CoV-2-specific memory CD4+ and CD8+ T cells are present in up to 50% of unexposed, pre-pandemic, healthy individuals (UPPHIs). However, the characteristics of cross-reactive memory CD4+ and CD8+ T cells associated with subsequent protection of asymptomatic coronavirus disease 2019 (COVID-19) patients (i.e., unvaccinated individuals who never develop any COVID-19 symptoms despite being infected with SARS-CoV-2) remains to be fully elucidated. Methods: This study compares the antigen specificity, frequency, phenotype, and function of cross-reactive memory CD4+ and CD8+ T cells between common cold coronaviruses (CCCs) and SARS-CoV-2. T-cell responses against genome-wide conserved epitopes were studied early in the disease course in a cohort of 147 unvaccinated COVID-19 patients who were divided into six groups based on the severity of their symptoms. Results: Compared to severely ill COVID-19 patients and patients with fatal COVID-19 outcomes, the asymptomatic COVID-19 patients displayed significantly: (i) higher rates of co-infection with the 229E alpha species of CCCs (a-CCC-229E); (i i) higher frequencies of cross-reactive functional CD134+CD137+CD4+ and CD134+CD137+CD8+ T cells that cross-recognized conserved epitopes from a-CCCs and SARS-CoV-2 structural, non-structural, and accessory proteins; and (iii) lower frequencies of CCCs/SARS-CoV-2 cross-reactive exhausted PD-1+TIM3+TIGIT+CTLA4+CD4+ and PD-1+TIM3+TIGIT+CTLA4+CD8+ T cells, detected both ex vivo and in vitro. Conclusions: These findings (i) support a crucial role of functional, poly-antigenic a-CCCs/SARS-CoV-2 cross-reactive memory CD4+ and CD8+ T cells, induced following previous CCCs seasonal exposures, in protection against subsequent severe COVID-19 disease and (ii) provide critical insights into developing broadly protective, multi-antigen, CD4+, and CD8+ T-cell-based, universal pan-Coronavirus vaccines capable of conferring cross-species protection. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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