التفاصيل البيبلوغرافية
| العنوان: |
Quantification of (9R)‐ and (9S)‐hexahydrocannabinol (HHC) via GC–MS in serum/plasma samples from drivers suspected of cannabis consumption and immunological detection of HHC and related substances in serum, urine, and saliva. |
| المؤلفون: |
Höfert, Lisa, Becker, Susen, Dreßler, Jan, Baumann, Sven |
| المصدر: |
Drug Testing & Analysis; May2024, Vol. 16 Issue 5, p489-497, 9p |
| مستخلص: |
The semisynthetic cannabinoid hexahydrocannabinol (HHC) is currently getting a lot of media attention because the legal status in many countries is not clearly specified. In this study, a GC–MS method for the quantification of Δ9‐tetrahydrocannabinol (THC), 11‐hydroxy‐Δ9‐tetrahydrocannabinol (11‐OH‐THC), and 11‐nor‐9‐carboxy‐Δ9‐tetrahydrocannabinol (THC‐COOH) was extended to (9R)‐ and (9S)‐HHC. The applicability was proven by serum/plasma samples from drivers suspected of cannabis consumption. Limit of detection (LOD) and lower limit of quantification (LLOQ) were 0.15 and 0.25 ng/mL, respectively. Within‐run imprecision was <6.5% and between‐run imprecision was <10.0%. Inter‐injection stability, processed sample stability (3 days), freeze–thaw stability (three cycles), and storage stability (1 week room temperature; 1 month 4°C, −20°C) could be proven. Both HHC diastereomers could be detected in 17 (5.3%) out of 321 analyzed samples from traffic controls in Western Saxony. The mean ratio between (9R)‐ and (9S)‐HHC was 1.99 (CV = 14.6%). Quantification resulted in concentrations between
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| قاعدة البيانات: |
Complementary Index |
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