التفاصيل البيبلوغرافية
| العنوان: |
Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants. |
| المؤلفون: |
Thümmler, Laura, Beckmann, Nadine, Sehl, Carolin, Soddemann, Matthias, Braß, Peer, Bormann, Maren, Brochhagen, Leonie, Elsner, Carina, Hoertel, Nicolas, Cougoule, Céline, Ciesek, Sandra, Widera, Marek, Dittmer, Ulf, Lindemann, Monika, Horn, Peter A., Witzke, Oliver, Kadow, Stephanie, Kamler, Markus, Gulbins, Erich, Becker, Katrin Anne |
| المصدر: |
Viruses (1999-4915); Apr2024, Vol. 16 Issue 4, p545, 15p |
| مصطلحات موضوعية: |
SARS-CoV-2, SERTRALINE, FLUOXETINE, SARS-CoV-2 Omicron variant, CLINICAL trials |
| مستخلص: |
The pandemic caused by SARS-CoV-2 is still a major health problem. Newly emerging variants and long-COVID-19 represent a challenge for the global health system. In particular, individuals in developing countries with insufficient health care need easily accessible, affordable and effective treatments of COVID-19. Previous studies have demonstrated the efficacy of functional inhibitors of acid sphingomyelinase against infections with various viruses, including early variants of SARS-CoV-2. This work investigated whether the acid sphingomyelinase inhibitors fluoxetine and sertraline, usually used as antidepressant molecules in clinical practice, can inhibit the replication of the former and recently emerged SARS-CoV-2 variants in vitro. Fluoxetine and sertraline potently inhibited the infection with pseudotyped virus-like particles and SARS-CoV-2 variants D614G, alpha, delta, omicron BA.1 and omicron BA.5. These results highlight fluoxetine and sertraline as priority candidates for large-scale phase 3 clinical trials at different stages of SARS-CoV-2 infections, either alone or in combination with other medications. [ABSTRACT FROM AUTHOR] |
|
Copyright of Viruses (1999-4915) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder