التفاصيل البيبلوغرافية
| العنوان: |
Manganese(I)‐Catalyzed Enantioselective C(sp2)−C(sp3) Bond‐Forming for the Synthesis of Skipped Dienes with Synergistic Aminocatalysis. |
| المؤلفون: |
Zhao, Chuan‐Gang, Cai, Junzhe, Du, Chaoyu, Gao, Qi, Han, Jie, Xie, Jin |
| المصدر: |
Angewandte Chemie International Edition; May2024, Vol. 63 Issue 19, p1-8, 8p |
| مصطلحات موضوعية: |
DIOLEFINS, HOMOGENEOUS catalysis, MANGANESE, BORONIC acids, TRIENES, ALDEHYDES |
| مستخلص: |
Mn(I)‐catalyzed enantioselective C−C bond‐forming reactions represent a great challenge in homogeneous catalysis primarily due to a limited understanding of its mechanistic principles. Herein, we have developed an interesting catalytic strategy that leverages a synergistic combination of a dimeric manganese(I) catalyst and a chiral aminocatalyst to address this issue. A range of conjugated dienals and trienals can exclusively proceed 1,4‐hydroalkenylation by using readily available aromatic and aliphatic alkenyl boronic acids as coupling partners, producing a rich library of skipped diene aldehydes in synthetically useful yields and high levels of enantioselectivities. Notably, downstream transformations of these products can not only afford a concise approach to construct enantioenriched skipped trienes but also realize enantioselective total synthesis of analogues to (−)‐Blepharocalyxin D in four steps. DFT calculations suggest the 1,4‐hydroalkenylation is kinetically more favorable than 1,6‐hydroalkenylation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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