دورية أكاديمية

Fluoride‐treated rare earth‐free magnesium alloy ZK30: An inert and bioresorbable material for bone fracture treatment devices.

التفاصيل البيبلوغرافية
العنوان: Fluoride‐treated rare earth‐free magnesium alloy ZK30: An inert and bioresorbable material for bone fracture treatment devices.
المؤلفون: Watanabe, Hirotaka, Xu, Wei, Uno, Haruka, Uraya, Yuki, Kugita, Masanori, Komohara, Yoshihiro, Niidome, Takuro, Sasaki, Makoto, Shimizu, Ichiro, Fujita, Nobuyuki, Kawano, Yusuke
المصدر: Journal of Biomedical Materials Research, Part A; Jul2024, Vol. 112 Issue 7, p963-972, 10p
مستخلص: Bone fractures represent a common health problem, particularly in an increasingly aging population. Bioresorbable magnesium (Mg) alloy‐based implants offer promising alternatives to traditional metallic implants for the treatment of bone fractures because they eliminate the need for implant removal after healing. The Mg‐Y‐rare‐earth (RE)‐Zr alloy WE43, designed for orthopedic implants, has received European Conformity mark approval. However, currently, WE43 is not clinically used in certain countries possibly because of concerns related to RE metals. In this study, we investigated the use of a RE‐free alloy, namely, Mg‐Zn‐Zr alloy (ZK30), as an implant for bone fractures. Hydrofluoric acid (HF) treatment was performed to improve the corrosion resistance of ZK30. HF‐treated ZK30 (HF‐ZK30) exhibited lower corrosion rate and higher biocompatibility than those of WE43 in in vitro experiments. After implanting a rod of HF‐ZK30 into the fractured femoral bones of mice, HF‐ZK30 held the bones and healed the fracture without deformation. Treatment results of HF‐ZK30 were comparable to those of WE43, indicating the potential of HF‐ZK30 as a bioresorbable and safe implant for bone repair. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biomedical Materials Research, Part A is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
قاعدة البيانات: Complementary Index
الوصف
تدمد:15493296
DOI:10.1002/jbm.a.37673