التفاصيل البيبلوغرافية
| العنوان: |
Optical coherence tomography choroidal enhancement using generative deep learning. |
| المؤلفون: |
Bellemo, Valentina, Kumar Das, Ankit, Sreng, Syna, Chua, Jacqueline, Wong, Damon, Shah, Janika, Jonas, Rahul, Tan, Bingyao, Liu, Xinyu, Xu, Xinxing, Tan, Gavin Siew Wei, Agrawal, Rupesh, Ting, Daniel Shu Wei, Yong, Liu, Schmetterer, Leopold |
| المصدر: |
NPJ Digital Medicine; 5/4/2024, Vol. 7 Issue 1, p1-12, 12p |
| مصطلحات موضوعية: |
RETINA physiology, UVEA, PEARSON correlation (Statistics), GLAUCOMA, OPTICAL coherence tomography, RETINAL diseases, DIABETIC retinopathy, TERTIARY care, VISUALIZATION, DEEP learning |
| مستخلص: |
Spectral-domain optical coherence tomography (SDOCT) is the gold standard of imaging the eye in clinics. Penetration depth with such devices is, however, limited and visualization of the choroid, which is essential for diagnosing chorioretinal disease, remains limited. Whereas swept-source OCT (SSOCT) devices allow for visualization of the choroid these instruments are expensive and availability in praxis is limited. We present an artificial intelligence (AI)-based solution to enhance the visualization of the choroid in OCT scans and allow for quantitative measurements of choroidal metrics using generative deep learning (DL). Synthetically enhanced SDOCT B-scans with improved choroidal visibility were generated, leveraging matching images to learn deep anatomical features during the training. Using a single-center tertiary eye care institution cohort comprising a total of 362 SDOCT-SSOCT paired subjects, we trained our model with 150,784 images from 410 healthy, 192 glaucoma, and 133 diabetic retinopathy eyes. An independent external test dataset of 37,376 images from 146 eyes was deployed to assess the authenticity and quality of the synthetically enhanced SDOCT images. Experts' ability to differentiate real versus synthetic images was poor (47.5% accuracy). Measurements of choroidal thickness, area, volume, and vascularity index, from the reference SSOCT and synthetically enhanced SDOCT, showed high Pearson's correlations of 0.97 [95% CI: 0.96–0.98], 0.97 [0.95–0.98], 0.95 [0.92–0.98], and 0.87 [0.83–0.91], with intra-class correlation values of 0.99 [0.98–0.99], 0.98 [0.98–0.99], and 0.95 [0.96–0.98], 0.93 [0.91–0.95], respectively. Thus, our DL generative model successfully generated realistic enhanced SDOCT data that is indistinguishable from SSOCT images providing improved visualization of the choroid. This technology enabled accurate measurements of choroidal metrics previously limited by the imaging depth constraints of SDOCT. The findings open new possibilities for utilizing affordable SDOCT devices in studying the choroid in both healthy and pathological conditions. [ABSTRACT FROM AUTHOR] |
|
Copyright of NPJ Digital Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder