التفاصيل البيبلوغرافية
| العنوان: |
Neurofilament light chain but not glial fibrillary acidic protein is a potential biomarker of overt hepatic encephalopathy in patients with cirrhosis. |
| المؤلفون: |
de Wit, Koos, van Doorn, Diederick J., Mol, Bregje, van Vught, Lonneke A., Nevens, Frederik, Beuers, Ulrich, Ponsioen, Cyriel Y., Teunissen, Charlotte E., Takkenberg, R. Bart |
| المصدر: |
Annals of Hepatology: Official Journal of the Mexican Association of Hepatology; May/Jun2024, Vol. 29 Issue 3, p1-6, 6p |
| مصطلحات موضوعية: |
GLIAL fibrillary acidic protein, HEPATIC encephalopathy, CYTOPLASMIC filaments, CIRRHOSIS of the liver, BIOMARKERS |
| مستخلص: |
Introduction and Objectives: Hepatic encephalopathy (HE) is a frequent complication of cirrhosis and may cause cerebral damage. Neurodegenerative diseases can induce the release of neuroproteins like neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in body fluids, including blood plasma. We investigated whether NfL and GFAP could serve as potential diagnostic plasma biomarkers for overt HE (oHE). Materials and Methods: We included 85 patients from three prospective cohorts with different stages of liver disease and HE severity. The following patients were included: 1) 34 patients with primary sclerosing cholangitis (PSC) with compensated disease; 2) 17 patients with advanced liver disease without oHE before elective transjugular intrahepatic portosystemic shunt (TIPS) placement; 3) 17 intensive care unit (ICU) patients with oHE and 17 ICU patients without cirrhosis or oHE. Plasma NfL and GFAP were measured using single molecule assays. Results: ICU oHE patients had higher NfL concentrations compared to pre-TIPS patients or ICU controls (p < 0.05, each). Median GFAP concentrations were equal in the ICU oHE and pre-TIPS patients or ICU controls. Plasma NfL and GFAP concentrations correlated with Model for End-Stage Liver Disease (MELD) scores (R = 0.58 and R = 0.40, p < 0.001, each). Conclusions: Plasma NfL deserves further evaluation as potential diagnostic biomarker for oHE and correlates with the MELD score. [ABSTRACT FROM AUTHOR] |
|
Copyright of Annals of Hepatology: Official Journal of the Mexican Association of Hepatology is the property of Fundacion Clinica Medica Sur and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text via ClinicalKey 
Full Text Finder