التفاصيل البيبلوغرافية
| العنوان: |
Prognostic Role of p53 Immunohistochemical Status in Invasive Breast Cancer. A Retrospective Review of 1387 Cases With Luminal-Like/Her2 Negative Breast Tumors. |
| المؤلفون: |
Dajti, Gerti, Serra, Margherita, Cisternino, Giovanni, Ceccarelli, Claudio, Pellegrini, Alice, Melina, Marica, Leo, Antonio De, Santini, Donatella, Taffurelli, Mario, Zanotti, Simone |
| المصدر: |
Oncologist; May2024, Vol. 29 Issue 5, p384-391, 8p |
| مصطلحات موضوعية: |
BREAST cancer prognosis, PROGESTERONE, IMMUNOPHENOTYPING, RESEARCH funding, BREAST tumors, RETROSPECTIVE studies, IMMUNOHISTOCHEMISTRY, GENE expression, PROGRESSION-free survival, CONFIDENCE intervals, GENETIC mutation |
| مستخلص: |
Purpose The aim of this study was to evaluate the prognostic role of p53 immunohistochemical (IHC) expression in a large cohort of patients with hormone receptors (HR)-positive/Her2-negative primary invasive breast cancer. Methods Retrospective review of consecutive cases treated at our Breast Unit between 2003 and 2013. Patients were divided into 3 subgroups based on p53 IHC expression: null (0%), low (0.1%-49%), and high (≥50%) p53 expression. Results A total of 1387 patients were included in the study with a median follow-up of 86 months. After adjusting for age, size, node status, lymphovascular invasion, progesterone, and Ki67 expression, only null p53 immunophenotype was associated with worse disease-free survival (DFS) (OR 1.74, 95% IC, 1.11-2.71, P = .015) and distant recurrence-free survival (DRFS) (OR 1.73, 95% IC, 1.04-2.90, P = .036). Null p53 impacted significantly DFS and DRFS also in patients with early breast cancer. Conclusions p53 IHC expression affects survival and, thus can be a valuable tool in the management of patients with HR-positive/Her2-negative breast cancer [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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