التفاصيل البيبلوغرافية
| العنوان: |
Investigation of air bubble behaviour after gas embolism events induced in a microfluidic network mimicking microvasculature. |
| المؤلفون: |
Mardanpour, Mohammad Mahdi, Perumal, Ayyappasamy Sudalaiyadum, Mahmoodi, Zahra, Baassiri, Karine, Montiel-Rubies, Gala, LeDez, Kenneth M., Nicolau, Dan V. |
| المصدر: |
Lab on a Chip; 5/7/2024, Vol. 24 Issue 9, p2518-2536, 19p |
| مصطلحات موضوعية: |
GAS embolism, BUBBLES, AIR resistance, BLOOD substitutes, VISCOSITY, MICROFLUIDIC devices |
| مستخلص: |
Gas embolism is a medical condition that occurs when gas bubbles are present in veins or arteries, decreasing blood flow and potentially reducing oxygen delivery to vital organs, such as the brain. Although usually reported as rare, gas embolism can lead to severe neurological damage or death. However, presently, only limited understanding exists regarding the microscale processes leading to the formation, persistence, movement, and resolution of gas emboli, as modulated by microvasculature geometrical features and blood properties. Because gas embolism is initially a physico-chemical-only process, with biological responses starting later, the opportunity exists to fully study the genesis and evolution of gas emboli using in vitro microfluidic networks mimicking small regions of microvasculature. The microfluidics networks used in this study, which aim to mimic microvasculature geometry, comprise linear channels with T-, or Y-junction air inlets, with 20, 40, and 60 μm widths (arterial or venous), and a 30 μm width honeycombed network (arterial) with three bifurcation angles (30°, 60°, and 90°). Synthetic blood, equivalent to 46% haematocrit concentrations, and water were used to study the modulation of gas embolism-like events by liquid viscosity. Our study shows that (i) longer bubbles with lower velocity occur in narrower channels, e.g., with 20 μm width; (ii) the resistance of air bubbles to the flow increases with the higher haematocrit concentration; and lastly (iii) the propensity of gas embolism-like events in honeycomb architectures increases for more acute, e.g., 30°, bifurcation angles. A dimensionless analysis using Euler, Weber, and capillary numbers demarcated the conditions conducive to gas embolism. This work suggests that in vitro experimentation using microfluidic devices with microvascular tissue-like structures could assist medical guidelines and management in preventing and mitigating the effects of gas embolism. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
