التفاصيل البيبلوغرافية
| العنوان: |
Effects of aerobic and resistance exercise for 9 months on serum free light chains in type 2 diabetes. |
| المؤلفون: |
Youyoung Kim, Campbell, John P., Johannsen, Neil M., Church, Timothy S., Cho, Eunhan, Heaney, Jennifer, Spielmann, Guillaume |
| المصدر: |
Frontiers in Physiology; 2024, p1-13, 13p |
| مصطلحات موضوعية: |
IMMUNOGLOBULIN light chains, TYPE 2 diabetes, AEROBIC exercises, RESISTANCE training, EXERCISE therapy |
| مستخلص: |
Background and aims: Serum polyclonal free light chains (FLCs) levels are associated with overall survival in the general population, reflecting their utility as a biomarker of underlying immune activation and inflammation. Regular exercise is known to ameliorate low-grade inflammation in chronic diseases such as type 2 diabetes; however, the effects of different exercise training modalities on FLCs in adults with type 2 diabetes is unknown. This study investigated the effects of 9-month of aerobic, resistance or combined supervised exercise on serum FLCs in 164 patients with type 2 diabetes (age 58 ± 8 years; 63% female). Methods: 164 participants from the Health Benefits of Aerobic and Resistance Training in individuals with type 2 diabetes trial (HART-D) were randomly assigned to no exercise (n = 27), aerobic exercise alone (n = 41), resistance exercise alone (n = 49), or a combination of aerobic and resistance exercise (n = 47). Fasting serum samples were collected before and after completion of the intervention to quantify changes in kappa and lambda FLCs, and serum creatinine, using commercially-available ELISAs. Results: At baseline, combined kappa and lambda FLCs (FLC sum; calculated as kappa + lambda FLCs) were positively correlated with high-sensitive C-reactive protein (hs-CRP) (r = 0.237, p < 0.05) and fat mass (r = 0.162, p < 0.05), and negatively associated with aerobic fitness (r = -0.238, p < 0.05). While nonexercise controls exhibited an increase in FLCs over the 9-month study, exercise training blunted this increase (FLC sum control arm: 3.25 ± 5.07 mg·L-1 vs. all exercise arms: -0.252 ± 6.60 mg·L-1, p < 0.05), regardless of exercise modality. Conclusion: Serum FLCs were associated with physical fitness and body composition in patients with type 2 diabetes. 9-month of exercise training prevented the accumulation of FLCs, regardless of exercise modality. Unlike hs-CRP--which did not change during the trial--serum FLCs may serve as a more sensitive biomarker of chronic low-grade inflammation in this population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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