التفاصيل البيبلوغرافية
| العنوان: |
P16/Ki67 Dual Staining in Glandular Cell Abnormalities of the Uterine Cervix. |
| المؤلفون: |
Jeromel, Saša, Repše Fokter, Alenka, Dovnik, Andraž |
| المصدر: |
Cancers; May2024, Vol. 16 Issue 9, p1621, 11p |
| مصطلحات موضوعية: |
ADENOCARCINOMA, SQUAMOUS cell carcinoma, CERVIX uteri tumors, TUMOR markers, RETROSPECTIVE studies, DESCRIPTIVE statistics, LONGITUDINAL method, STAINS & staining (Microscopy), DATA analysis software, EPITHELIAL cell tumors, SENSITIVITY & specificity (Statistics) |
| مستخلص: |
Simple Summary: The triage of glandular cell abnormalities of the uterine cervix poses many challenges due to high interobserver variability. p16/Ki67 dual staining has been proposed as an objective test that could decrease interobserver variability in diagnosing atypical glandular cells. Our results indicate the possible role of p17/Ki67 dual staining in triaging glandular cell abnormalities. Very limited information exists about the role of p16/Ki67 dual staining on glandular cells in detecting glandular precancerous lesions and cervical adenocarcinoma. In this study, we investigated the diagnostic accuracy of p16/Ki67 dual staining for the detection of glandular and squamous lesions on the uterine cervix and for cancer of the upper reproductive tract. We performed a retrospective analysis of prospectively collected data on 96 patients with glandular cell abnormalities. We analyzed the diagnostic accuracy of p16/Ki67 dual staining for atypical glandular cells, not otherwise specified (AGC-NOS); atypical glandular cells, favor neoplastic (AGC-FN); adenocarcinoma in situ (AIS); and A-CA (cervical adenocarcinoma). A separate analysis for the detection of squamous precancerous lesions and squamous-cell carcinoma (CIN3+) and for cancer of the upper reproductive tract (EC/OC) was performed. Among patients who had normal histology or a low-grade lesion on final analysis, only 8.5% had positive dual staining. On the other hand, 85.7% of patients with AIS+ on final histology had positive dual staining. The respective specificities of p16/Ki67 dual staining on AGC-NOS for the detection of AIS+ (adenocarcinoma in situ or cervical adenocarcinoma), CIN3+ and EC/OC were 91.5%, 88.7% and 86.4%. High specificity values of p16/Ki67 dual staining on cervical smears labelled as AGC-NOS for the detection of CIN3+ and AIS+ suggest that this method might be a useful addition in cervical cancer screening. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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