التفاصيل البيبلوغرافية
| العنوان: |
Subthalamic nucleus synchronization between beta band local field potential and single‐unit activity in Parkinson's disease. |
| المؤلفون: |
Bayman, Eric, Chee, Keanu, Mendlen, Madelyn, Denman, Daniel J., Tien, Rex N., Ojemann, Steven, Kramer, Daniel R., Thompson, John A. |
| المصدر: |
Physiological Reports; May2024, Vol. 12 Issue 9, p1-10, 10p |
| مصطلحات موضوعية: |
PARKINSON'S disease, SUBTHALAMIC nucleus, SYNCHRONIZATION, THERAPEUTICS |
| مستخلص: |
Local field potential (LFP) oscillations in the beta band (13–30 Hz) in the subthalamic nucleus (STN) of Parkinson's disease patients have been implicated in disease severity and treatment response. The relationship between single‐neuron activity in the STN and regional beta power changes remains unclear. We used spike‐triggered average (STA) to assess beta synchronization in STN. Beta power and STA magnitude at the beta frequency range were compared in three conditions: STN versus other subcortical structures, dorsal versus ventral STN, and high versus low beta power STN recordings. Magnitude of STA‐LFP was greater within the STN compared to extra‐STN structures along the trajectory path, despite no difference in percentage of the total power. Within the STN, there was a higher percent beta power in dorsal compared to ventral STN but no difference in STA‐LFP magnitude. Further refining the comparison to high versus low beta peak power recordings inside the STN to evaluate if single‐unit activity synchronized more strongly with beta band activity in areas of high beta power resulted in a significantly higher STA magnitude for areas of high beta power. Overall, these results suggest that STN single units strongly synchronize to beta activity, particularly units in areas of high beta power. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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