التفاصيل البيبلوغرافية
العنوان: |
A Novel Route towards Bicyclo[1.1.1]pentane Sulfoxides from a Bench-Stable Starting Material. |
المؤلفون: |
Langer, Lukas S., Stahlberger, Mareen, Bär, Robin M., Bräse, Stefan |
المصدر: |
Synlett; Jun2024, Vol. 35 Issue 9, p1023-1027, 5p |
مصطلحات موضوعية: |
PENTANE, SULFOXIDES |
مستخلص: |
This article explores the use of bicyclopentane (BCP) as a bioisostere in medicinal chemistry. BCP can replace phenyl rings or alkynes in molecules, altering their physical properties. The authors focus on the synthesis of BCP-sulfoxides, which can enhance the pharmacological properties of compounds. They present a new method using a BCP-sulfinate precursor that is more convenient and stable. The authors successfully synthesized a previously inaccessible methyl-substituted sulfoxide and suggest the potential for further modifications. [Extracted from the article] |
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قاعدة البيانات: |
Complementary Index |