التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of Cyclin-Dependent Kinase Inhibitor 2A and Hepatocyte Nuclear Factor-1A Gene Polymorphisms in Coronary Artery Diseases. |
| المؤلفون: |
Ibrahimm, Magdy, Sherif, Abdelsalam, Mohamed, Dina Salah, Samy, Walaa |
| المصدر: |
Zagazig University Medical Journal; May/Jun2024, Vol. 30 Issue 3, p859-867, 10p |
| مصطلحات موضوعية: |
CYCLIN-dependent kinase inhibitors, CORONARY artery disease, GENETIC polymorphisms, CORONARY disease |
| مستخلص: |
Background: Blood lipid-regulating and cell proliferation-regulating genes have both been connected to the development of coronary artery disease (CAD),we aimed to find the correlation between CDKN2A rs3088440, HNF1A rs55783344CT gene polymorphisms and CAD. Methods : One hundred and six participants were subjected to this casecontrol study; case group I: patients with CHD and control group II: Normal healthy people. Subjects underwent a comprehensive history and physical examination, standard laboratory tests, and coronary angiograms. CDKN2A rs3088440 and HNF1A rs55783344CT gene polymorphisms was done by (PCR-RFLP).Results: CT genotype and CT+TT of HNF1AC were statistically Signiant higher in CAD cases than controls. T allele of HNF1AC was much higher in CAD cases than controls, with a significant difference between 2 groups. Proportion of those with the CDKN2A GA+AA genotype in the CAD patients was significantly higher than in the control group. Also, the frequency of the CDKN2A A allele was significantly different between CAD cases and controls.Conclusions: Coronary heart disease (CHD) has a complex etiopathogenesis and a multifactorial origin. SNPs are potential risk factors of CHD. CDKN2A rs3088440 (G>A) and HNF1A rs55783344CT gene polymorphisms be a factor in pathogenesis of CHD. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
