التفاصيل البيبلوغرافية
| العنوان: |
Advancements in super-selective catheterization and drug selection for intra-arterial chemotherapy for retinoblastoma: a 15-year evolution. |
| المؤلفون: |
Kocharian, Gary, Gobin, Y. Pierre, Kharas, Natasha, Knopman, Jared, Francis, Jasmine H., Abramson, David H. |
| المصدر: |
Journal of NeuroInterventional Surgery; Apr2024, Vol. 16 Issue 4, p398-404, 7p |
| مصطلحات موضوعية: |
VISION disorders, EYE, RESEARCH funding, SALVAGE therapy, CATHETERIZATION, RETROSPECTIVE studies, RETINOBLASTOMA, CANCER chemotherapy, MEDICAL records, ACQUISITION of data, TIME |
| مستخلص: |
Background Retinoblastoma (Rb) is the most common primary ocular malignancy of childhood. Left untreated, it is 100% fatal and carries a substantial risk of impaired vision and removal of one or both eyes. Intra-arterial chemotherapy (IAC) has become a pillar in the treatment paradigm for Rb that allows for better eye salvage and vision preservation without compromising survival. We describe the evolution of our technique over 15 years. Methods A retrospective chart review was conducted of 571 patients (697 eyes) and 2391 successful IAC sessions over 15 years. This cohort was separated into three 5-year periods (P1, P2, P3) to assess trends in IAC catheterization technique, complications, and drug delivery. Results From a total of 2402 attempted IAC sessions, there were 2391 successful IAC deliveries, consistent with a 99.5% success rate. The rate of successful super-selective catheterizations over the three periods ranged from 80% in P1 to 84.9% in P2 and 89.2% in P3. Catheterization-related complication rates were 0.7% in P1, 1.1% in P2, and 0.6% in P3. Chemotherapeutics used included combinations of melphalan, topotecan and carboplatin. The rate of patients receiving triple therapy among all groups was 128 (21%) in P1, 487 (41.9%) in P2, and 413 (66.7%) in P3. Conclusions The overall rate of successful catheterization and IAC started high and has improved over 15 years, and catheterization-related complications are rare. There has been a significant trend towards triple chemotherapy over time. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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