التفاصيل البيبلوغرافية
| العنوان: |
Unveiling the Potential of Single‐Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives. |
| المؤلفون: |
Pires‐Santos, Manuel, Nadine, Sara, Mano, João F. |
| المصدر: |
Small Science; May2024, Vol. 4 Issue 5, p1-21, 21p |
| مصطلحات موضوعية: |
TARGETED drug delivery, POISSON distribution, CELL culture, BIOPRINTING, HIGH throughput screening (Drug development), DRUG carriers |
| مستخلص: |
The encapsulation of single cells has emerged as a promising field in recent years, owing to its potential applications in cell‐based therapeutics, bioprinting, in vitro cell culture, high‐throughput screening, and diagnostics. Single‐cell units offer several advantages, including compatibility with standard imaging techniques, superior diffusion rates, and lower material‐to‐cell volume ratios. They also serve as effective carriers for targeted drug delivery, allowing precise administration of therapeutics in cell‐mediated quantities. Moreover, single‐cell units exhibit improved circulation potential throughout the vasculature, with a reduced likelihood of entrapment compared to multicell strategies. However, the production of single‐cell units from random dispersion of cells follows the Poisson distribution, requiring the separation of empty and multicell units from single‐cell ones. Various methods have been developed to address this challenge; nevertheless, the majority of these strategies are either expensive or time‐consuming. This review provides an in‐depth analysis of the advantages and limitations of single‐cell units and their applications, as well as a comprehensive overview of the most used techniques for single‐cell encapsulation and sorting strategies. [ABSTRACT FROM AUTHOR] |
|
Copyright of Small Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
