التفاصيل البيبلوغرافية
| العنوان: |
Clinical and magnetic resonance imaging findings in a French bulldog puppy with genetically confirmed congenital hypothyroidism. |
| المؤلفون: |
González, Katia Sánchez, Warwick, Harry, Conradie, Marius, Alisauskaite, Neringa |
| المصدر: |
Journal of Veterinary Internal Medicine; May/Jun2024, Vol. 38 Issue 3, p1737-1743, 7p |
| مصطلحات موضوعية: |
MAGNETIC resonance imaging, CONGENITAL hypothyroidism, BULLDOG, CEREBRAL sulci, SYMPTOMS, IODIDE peroxidase |
| مستخلص: |
A 7‐month‐old male French bulldog was referred for abnormal mentation and gait. Physical examination revealed a dome shaped calvarium and persistent bregmatic fontanelle. Neurological examination revealed proprioceptive ataxia, pelvic limb paraparesis and strabismus with moderate ventriculomegaly, thinning of the cerebral parenchyma, and widened cerebral sulci on magnetic resonance imaging. Masses were identified in the region of the thyroid, which appeared heterogeneous and hyperintense in T1‐weighted and T2‐weighted compared with the adjacent muscle signal masses were identified. Radiological diagnosis was hydrocephalus "ex vacuo" and goiter. Blood test revealed abnormally low total thyroxine (TT4), free thyroxine (FT4), and normal thyrotropin concentration. A diagnosis of congenital hypothyroidism was confirmed by positive genetic test for thyroid peroxidase mutation. Thyroxine supplementation treatment rapidly improved clinical signs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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