التفاصيل البيبلوغرافية
| العنوان: |
linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability. |
| المؤلفون: |
O'Reilly, Marcella E., Ho, Sebastian, Coronel, Johana, Zhu, Lucie, Liu, Wen, Xue, Chenyi, Kim, Eunyoung, Cynn, Esther, Matias, Caio V., Soni, Rajesh Kumar, Wang, Chen, Ionita-Laza, Iuliana, Bauer, Robert C., Ross, Leila, Zhang, Yiying, Corvera, Silvia, Fried, Susan K., Reilly, Muredach P. |
| المصدر: |
Cell Reports; May2024, Vol. 43 Issue 5, pN.PAG-N.PAG, 1p |
| مستخلص: |
Adipose tissue remodeling and dysfunction, characterized by elevated inflammation and insulin resistance, play a central role in obesity-related development of type 2 diabetes (T2D) and cardiovascular diseases. Long intergenic non-coding RNAs (lincRNAs) are important regulators of cellular functions. Here, we describe the functions of linc-ADAIN (adipose anti-inflammatory), an adipose lincRNA that is downregulated in white adipose tissue of obese humans. We demonstrate that linc-ADAIN knockdown (KD) increases KLF5 and interleukin-8 (IL-8) mRNA stability and translation by interacting with IGF2BP2. Upregulation of KLF5 and IL-8, via linc-ADAIN KD, leads to an enhanced adipogenic program and adipose tissue inflammation, mirroring the obese state, in vitro and in vivo. KD of linc-ADAIN in human adipose stromal cell (ASC) hTERT adipocytes implanted into mice increases adipocyte size and macrophage infiltration compared to implanted control adipocytes, mimicking hallmark features of obesity-induced adipose tissue remodeling. linc-ADAIN is an anti-inflammatory lincRNA that limits adipose tissue expansion and lipid storage. [Display omitted] • linc-ADAIN expression increases during adipocyte differentiation • linc-ADAIN is suppressed in white adipose tissue of obese humans • Knockdown of linc-ADAIN leads to increased inflammation and sustained adipogenesis • linc-ADAIN knockdown increases IL-8 and KLF5 mRNA, important genes for adipogenesis O'Reilly et al. investigate a long non-coding RNA, named linc-adipose anti-inflammatory (linc-ADAIN), and its role in adipose inflammation and maturation of fat cells (adipocytes). They show that linc-ADAIN 's expression is suppressed in adipose tissue of obese humans and that linc-ADAIN regulates inflammation as well as maturation and size of fat cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
