التفاصيل البيبلوغرافية
| العنوان: |
Therapeutic Drug Monitoring and Biomarkers; towards Better Dosing of Antimicrobial Therapy. |
| المؤلفون: |
Wehbe, Eman, Patanwala, Asad E., Lu, Christine Y., Kim, Hannah Yejin, Stocker, Sophie L., Alffenaar, Jan-Willem C. |
| المصدر: |
Pharmaceutics; May2024, Vol. 16 Issue 5, p677, 13p |
| مصطلحات موضوعية: |
DRUG monitoring, DRUG utilization, BIOMARKERS, DRUG therapy, MEDICATION therapy management |
| مستخلص: |
Due to variability in pharmacokinetics and pharmacodynamics, clinical outcomes of antimicrobial drug therapy vary between patients. As such, personalised medication management, considering both pharmacokinetics and pharmacodynamics, is a growing concept of interest in the field of infectious diseases. Therapeutic drug monitoring is used to adjust and individualise drug regimens until predefined pharmacokinetic exposure targets are achieved. Minimum inhibitory concentration (drug susceptibility) is the best available pharmacodynamic parameter but is associated with many limitations. Identification of other pharmacodynamic parameters is necessary. Repurposing diagnostic biomarkers as pharmacodynamic parameters to evaluate treatment response is attractive. When combined with therapeutic drug monitoring, it could facilitate making more informed dosing decisions. We believe the approach has potential and justifies further research. [ABSTRACT FROM AUTHOR] |
|
Copyright of Pharmaceutics is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder