التفاصيل البيبلوغرافية
| العنوان: |
B-Factor Rescaling for Protein Crystal Structure Analyses. |
| المؤلفون: |
Mlynek, Georg, Djinović-Carugo, Kristina, Carugo, Oliviero |
| المصدر: |
Crystals (2073-4352); May2024, Vol. 14 Issue 5, p443, 14p |
| مصطلحات موضوعية: |
CRYSTALLOIDS (Botany), CRYSTAL structure, PROTEIN structure, ATOMIC displacements, CRYSTAL lattices |
| مستخلص: |
The B-factor, also known as the atomic displacement parameter, is a fundamental metric in crystallography for quantifying the positional flexibility of atoms within crystal lattices. In structural biology, various developments have expanded the use of B-factors beyond conventional crystallographic analysis, allowing for a deeper understanding of protein flexibility, enzyme manipulation, and an improved understanding of molecular dynamics. However, the interpretation of B-factors is complicated by their sensitivity to various experimental and computational factors, necessitating rigorous rescaling methods to ensure meaningful comparisons across different structures. This article provides an in-depth description of rescaling approaches used for B-factors. It includes an examination of several methods for managing conformational disorder and selecting the atom types required for the analysis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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