التفاصيل البيبلوغرافية
| العنوان: |
The Importance of HHLA2 in Solid Tumors—A Review of the Literature. |
| المؤلفون: |
Kula, Agnieszka, Koszewska, Dominika, Kot, Anna, Dawidowicz, Miriam, Mielcarska, Sylwia, Waniczek, Dariusz, Świętochowska, Elżbieta |
| المصدر: |
Cells (2073-4409); May2024, Vol. 13 Issue 10, p794, 25p |
| مصطلحات موضوعية: |
LITERATURE reviews, KILLER cells, CYTOTOXIC T lymphocyte-associated molecule-4, PROGRAMMED cell death 1 receptors, IMMUNE response, T cells |
| مستخلص: |
Cancer immunotherapy is a rapidly developing field of medicine that aims to use the host's immune mechanisms to inhibit and eliminate cancer cells. Antibodies targeting CTLA-4, PD-1, and its ligand PD-L1 are used in various cancer therapies. However, the most thoroughly researched pathway targeting PD-1/PD-L1 has many limitations, and multiple malignancies resist its effects. Human endogenous retrovirus-H Long repeat-associating 2 (HHLA2, known as B7H5/B7H7/B7y) is the youngest known molecule from the B7 family. HHLA2/TMIGD2/KIRD3DL3 is one of the critical pathways in modulating the immune response. Recent studies have demonstrated that HHLA2 has a double effect in modulating the immune system. The connection of HHLA2 with TMIGD2 induces T cell growth and cytokine production via an AKT-dependent signaling cascade. On the other hand, the binding of HHLA2 and KIR3DL3 leads to the inhibition of T cells and mediates tumor resistance against NK cells. This review aimed to summarize novel information about HHLA2, focusing on immunological mechanisms and clinical features of the HHLA2/KIR3DL3/TMIGD2 pathway in the context of potential strategies for malignancy treatment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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