التفاصيل البيبلوغرافية
| العنوان: |
MV140 Mucosal Vaccine Induces Targeted Immune Response for Enhanced Clearance of Uropathogenic E. coli in Experimental Urinary Tract Infection. |
| المؤلفون: |
Saz-Leal, Paula, Ligon, Marianne Morris, Diez-Rivero, Carmen María, García-Ayuso, Diego, Mohanty, Soumitra, Viñuela, Marcos, Real-Arévalo, Irene, Conejero, Laura, Brauner, Annelie, Subiza, José Luis, Mysorekar, Indira Uppugunduri |
| المصدر: |
Vaccines; May2024, Vol. 12 Issue 5, p535, 12p |
| مصطلحات موضوعية: |
ESCHERICHIA coli, URINARY tract infections, IMMUNE response, BLADDER, BACTERIAL vaccines |
| مستخلص: |
MV140 is an inactivated whole-cell bacterial mucosal vaccine with proven clinical efficacy against recurrent urinary tract infections (UTIs). These infections are primarily caused by uropathogenic E. coli (UPEC) strains, which are unique in their virulence factors and remarkably diverse. MV140 contains a non-UPEC strain, suggesting that it may induce an immune response against different UPEC-induced UTIs in patients. To verify this, we experimentally evaluated the cellular and humoral responses to UTI89, a prototypical UPEC strain, in mice vaccinated with MV140, as well as the degree of protection achieved in a UPEC UTI89 model of acute cystitis. The results show that both cellular (Th1/Th17) and antibody (IgG/IgA) responses to UTI89 were induced in MV140-immunized mice. MV140 vaccination resulted in an early increased clearance of UTI89 viable bacteria in the bladder and urine following transurethral infection. This was accompanied by a highly significant increase in CD4+ T cells in the bladder and an increase in urinary neutrophils. Collectively, our results support that MV140 induces cross-reactive humoral and cellular immune responses and cross-protection against UPEC strains. [ABSTRACT FROM AUTHOR] |
|
Copyright of Vaccines is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder