التفاصيل البيبلوغرافية
| العنوان: |
Bioactive Adrenomedullin (bio-ADM) as a Biomarker for Capillary Leak in Children with Congenital Heart Defects Undergoing Cardiac Surgery on Cardiopulmonary Bypass (CPB). |
| المؤلفون: |
Schäfer, M., Stein, A., Balling, G., Ruf, B., Palm, J., Andreas, S., Cleuziou, J., Sander, M., Auer, J., Borgmann, K., Struck, J., Hartmann, O., Schulte, J., Hörer, J., Tassani-Prell, P., Ewert, P., Holdenrieder, S., Wolf, C. M. |
| المصدر: |
Thoracic & Cardiovascular Surgeon; 2024 Supplement2, Vol. 72, pS69-S96, 28p |
| مصطلحات موضوعية: |
CARDIOPULMONARY bypass, CARDIAC surgery, CONGENITAL heart disease, ADRENOMEDULLIN, BIOMARKERS, CAPILLARIES |
| مستخلص: |
This article discusses the use of bioactive adrenomedullin (bio-ADM) as a biomarker for capillary leak in children with congenital heart defects (CHD) undergoing cardiac surgery on cardiopulmonary bypass (CPB). The study included 73 pediatric patients with CHD, and plasma samples were collected at different time points before, during, and after surgery. The results showed that bio-ADM levels increased after surgery, with peak levels at 24 hours postoperatively. Higher bio-ADM levels were associated with longer CPB time, increased fluid balance, greater demand for medication, and the need for hydrocortisone therapy. The study suggests that bio-ADM could be considered as a biomarker for capillary leak in this patient population. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
