التفاصيل البيبلوغرافية
| العنوان: |
Navigating resistance to ALK inhibitors in the lorlatinib era: a comprehensive perspective on NSCLC. |
| المؤلفون: |
Gemelli, Maria, Albini, Adriana, Catalano, Gianpiero, Incarbone, Matteo, Cannone, Maria, Balladore, Emanuela, Ricotta, Riccardo, Pelosi, Giuseppe |
| المصدر: |
Expert Review of Anticancer Therapy; Jun2024, Vol. 24 Issue 6, p347-361, 15p |
| مصطلحات موضوعية: |
ANAPLASTIC lymphoma kinase, NON-small-cell lung carcinoma |
| مستخلص: |
The emergence of anaplastic lymphoma kinase (ALK) rearrangements in non-small cell lung cancer (NSCLC) has revolutionized targeted therapy. This dynamic landscape, featuring novel ALK inhibitors and combination therapies, necessitates a profound understanding of resistance mechanisms for effective treatment strategies. Recognizing two primary categories – on-target and off-target resistance – underscores the need for comprehensive assessment. This review delves into the intricacies of resistance to ALK inhibitors, exploring complexities in identification and management. Molecular testing, pivotal for early detection and accurate diagnosis, forms the foundation for patient stratification and resistance management. The literature search methodology involved comprehensive exploration of Pubmed and Embase. The multifaceted perspective encompasses new therapeutic horizons, ongoing clinical trials, and their clinical implications post the recent approval of lorlatinib. Our expert opinion encapsulates the critical importance of understanding resistance mechanisms in the context of ALK inhibitors for shaping successful treatment approaches. With a focus on molecular testing and comprehensive assessment, this review contributes valuable insights to the evolving landscape of NSCLC therapy. [ABSTRACT FROM AUTHOR] |
|
Copyright of Expert Review of Anticancer Therapy is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
PDF full text from Publisher