التفاصيل البيبلوغرافية
| العنوان: |
Psilocybin does not induce the vulnerability marker HSP70 in neurons susceptible to Olney's lesions. |
| المؤلفون: |
Iorgu, Ana-Maria, Vasilescu, Andrei-Nicolae, Pfeiffer, Natascha, Spanagel, Rainer, Mallien, Anne Stephanie, Inta, Dragos, Gass, Peter |
| المصدر: |
European Archives of Psychiatry & Clinical Neuroscience; Jun2024, Vol. 274 Issue 4, p1013-1019, 7p |
| مصطلحات موضوعية: |
PSILOCYBIN, METHYL aspartate receptors, CINGULATE cortex, HEAT shock proteins, NEURONS, SEROTONIN syndrome |
| مستخلص: |
S-ketamine, a N-methyl-D-aspartate receptor (NMDAR) antagonist, and psilocybin, a 5-hydroxy-tryptamine (serotonin) 2A receptor (5-HT2AR) agonist, are reported as effective rapid-acting antidepressants. Both compounds increase glutamate signalling and evoke cortical hyperexcitation. S-ketamine induces neurotoxicity especially in the retrosplenial cortex (Olney's lesions). Whether psilocybin produces similar neurotoxic effects has so far not been investigated. We performed an immunohistochemical whole-brain mapping for heat shock protein 70 (HSP70) in rats treated with psilocybin, S-ketamine, and MK-801. In contrast to S-ketamine- and MK-801-treated animals, we did not detect any HSP70-positive neurons in retrosplenial cortex of rats treated with psilocybin. Our results suggest that psilocybin might be safer for clinical use compared to S-ketamine regarding neuronal damage. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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