التفاصيل البيبلوغرافية
| العنوان: |
Cardioprotective effect of intradialytic exercise on left atrial mechanics. |
| المؤلفون: |
Maufrais, Claire, Josse, Matthieu, Patrier, Laure, Grandperrin, Antoine, Isnard, Myriam, Turc-Baron, Cécile, Nottin, Stéphane, Mandigout, Stéphane, Cristol, Jean-Paul, Obert, Philippe |
| المصدر: |
American Journal of Physiology: Renal Physiology; May2024, Vol. 326 Issue 5, pF694-F703, 10p |
| مصطلحات موضوعية: |
LEFT heart atrium, GLOBAL longitudinal strain, AEROBIC exercises, CROSSOVER trials, CONFIDENCE intervals |
| مستخلص: |
Left atrial (LA) function plays a pivotal role in cardiac performance by modulating left ventricular (LV) function. Impairments in LV function are commonly reported during hemodialysis (HD), but available data describing changes in LA function are limited. There is growing evidence of the cardioprotective effect of intradialytic exercise (IDE) on LV function, but studies analyzing its effect on LA function are scarce. Our aim was to evaluate whether IDE can limit the severity of HD-induced impairment in LA myocardial function. In this prospective, open-label, two-center randomized crossover trial, 56 stable individuals receiving HD participated in 2 HD sessions in random order: standard HD and a session incorporating 30 min of aerobic exercise. LA and LV global longitudinal strains (GLSs) were obtained before and at peak stress of HD (i.e., 30 min before the HD ending). IDE totally eradicated the decline in LA reservoir strain observed during HD (estimated difference: 3.1%, 95% confidence interval: 0.4/5.8, P = 0.02), whereas it did not affect the other components of LA mechanics. A similar result favoring IDE intervention was also demonstrated on GLS changes over the HD procedure (P < 0.001). Between-session differences of changes in GLS and LA reservoir strain were correlated (r = −0.32, P = 0.03). The cardioprotective effect of IDE disappeared in patients with LA enlargement (i.e., LA volume index >34 mL/m2). In conclusion, even a short duration of IDE at moderate intensity is effective in preventing HD-associated decline in LA reservoir function. Further research is needed to explore the long-term benefits of IDE on LA function. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
