التفاصيل البيبلوغرافية
| العنوان: |
Plasma Neurofilament Light Relates to Divergent Default and Salience Network Connectivity in Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia. |
| المؤلفون: |
Chong, Joanna Su Xian, Tan, Yi Jayne, Koh, Amelia Jialing, Ting, Simon Kang Seng, Kandiah, Nagaendran, Ng, Adeline Su Lyn, Zhou, Juan Helen |
| المصدر: |
Journal of Alzheimer's Disease; 2024, Vol. 99 Issue 3, p965-980, 16p |
| مصطلحات موضوعية: |
ALZHEIMER'S disease, SALIENCE network, FRONTOTEMPORAL dementia, DEFAULT mode network, MONTREAL Cognitive Assessment |
| مستخلص: |
Background: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) show differential vulnerability to large-scale brain functional networks. Plasma neurofilament light (NfL), a promising biomarker of neurodegeneration, has been linked in AD patients to glucose metabolism changes in AD-related regions. However, it is unknown whether plasma NfL would be similarly associated with disease-specific functional connectivity changes in AD and bvFTD. Objective: Our study examined the associations between plasma NfL and functional connectivity of the default mode and salience networks in patients with AD and bvFTD. Methods: Plasma NfL and neuroimaging data from patients with bvFTD (n = 16) and AD or mild cognitive impairment (n = 38; AD + MCI) were analyzed. Seed-based functional connectivity maps of key regions within the default mode and salience networks were obtained and associated with plasma NfL in these patients. RESULTS: We demonstrated divergent associations between NfL and functional connectivity in AD + MCI and bvFTD patients. Specifically, AD + MCI patients showed lower default mode network functional connectivity with higher plasma NfL, while bvFTD patients showed lower salience network functional connectivity with higher plasma NfL. Further, lower NfL-related default mode network connectivity in AD + MCI patients was associated with lower Montreal Cognitive Assessment scores and higher Clinical Dementia Rating sum-of-boxes scores, although NfL-related salience network connectivity in bvFTD patients was not associated with Neuropsychiatric Inventory Questionnaire scores. CONCLUSIONS: Our findings indicate that plasma NfL is differentially associated with brain functional connectivity changes in AD and bvFTD. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
