التفاصيل البيبلوغرافية
| العنوان: |
SARS-CoV-2 NSP5 antagonizes MHC II expression by subverting histone deacetylase 2. |
| المؤلفون: |
Taefehshokr, Nima, Lac, Alex, Vrieze, Angela M., Dickson, Brandon H., Guo, Peter N., Jung, Catherine, Blythe, Eoin N., Fink, Corby, Aktar, Amena, Dikeakos, Jimmy D., Dekaban, Gregory A., Heit, Bryan |
| المصدر: |
Journal of Cell Science; May2024, Vol. 137 Issue 10, p1-18, 18p |
| مصطلحات موضوعية: |
GENE expression, TRANSCRIPTION factors, SARS-CoV-2, MAJOR histocompatibility complex, T cell receptors, ANTIGEN presentation |
| مستخلص: |
SARS-CoV-2 interferes with antigen presentation by downregulating major histocompatibility complex (MHC) II on antigen-presenting cells, but the mechanism mediating this process is unelucidated. Herein, analysis of protein and gene expression in human antigen-presenting cells reveals that MHC II is downregulated by the SARS-CoV-2 main protease, NSP5. This suppression of MHC II expression occurs via decreased expression of the MHC II regulatory protein CIITA. CIITA downregulation is independent of the proteolytic activity of NSP5, and rather, NSP5 delivers HDAC2 to the transcription factor IRF3 at an IRF-binding site within the CIITA promoter. Here, HDAC2 deacetylates and inactivates the CIITA promoter. This loss of CIITA expression prevents further expression of MHC II, with this suppression alleviated by ectopic expression of CIITA or knockdown of HDAC2. These results identify a mechanism by which SARS-CoV-2 limits MHC II expression, thereby delaying or weakening the subsequent adaptive immune response. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Cell Science is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
