التفاصيل البيبلوغرافية
| العنوان: |
Modeling heart failure with preserved ejection fraction in female mice: an elusive target. |
| المؤلفون: |
Hale, Taben M., Blackwood, Erik A. |
| المصدر: |
American Journal of Physiology: Heart & Circulatory Physiology; Jun2024, Vol. 326 Issue 6, pH1402-H1405, 4p |
| مصطلحات موضوعية: |
HEART failure, VENTRICULAR ejection fraction, GLOBAL longitudinal strain, EPICARDIAL adipose tissue |
| مستخلص: |
This article explores the topic of heart failure with preserved ejection fraction (HFpEF), a complex form of heart failure associated with obesity, hypertension, diabetes, and age. The lack of effective therapies and animal models has hindered research on HFpEF. The study focuses on the effects of menopause on female susceptibility to HFpEF using a mouse model, finding that female mice, regardless of reproductive status, were protected from cardiac deficits. The research highlights the need for further studies on the role of female reproductive senescence in HFpEF. The article also discusses the use of different strains of mice in modeling HFpEF and emphasizes the need for transparency in methodology and standardized assessments in preclinical HFpEF research. The authors suggest renaming HFpEF as "metabolic-senile cardiovascular disease" to better reflect its presentation in patients. The research was funded by various grants and the authors declare no conflicts of interest. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
