التفاصيل البيبلوغرافية
| العنوان: |
DEVELOPMENT OF AN ACCURATE UV SPECTROSCOPIC METHOD FOR TINIDAZOLE IN VAGINAL BUFFERS. |
| المؤلفون: |
Shah, Sakshi M., Momin, Ilyas H., Patel, Riya M., Shah, Shreeraj H. |
| المصدر: |
Indian Drugs; May2024, Vol. 61 Issue 5, p64-67, 4p |
| مصطلحات موضوعية: |
ABSORPTION spectra, CALIBRATION, SPECTROPHOTOMETERS |
| مستخلص: |
A precise UV spectroscopic method was developed for accurately quantifying tinidazole (TNZ) using the Shimadzu 1900i UV spectrophotometer. Different sample solutions containing TNZ were scanned across a range of concentration 6 μg mL-1 to 26 μg mL-1 between 200-400 nm, generating overlay TNZ spectra showing an absorption maximum at 318nm in vaginal buffer which is made up of phosphate buffer (PB) 4.2 pH with 2% Tween 80® LR and 4 mL of methanol. The construction of a six-point calibration curve demonstrated the linearity of TNZ within the 6-26 μg mL-1 concentration range. The regression equation derived from this calibration curve was subsequently employed to accurately determine the concentration in accuracy studies. In the analysis of bulk TNZ, a recovery rate ranging from 98.41% to 102.28% was achieved. The analysis results were validated following ICH (International Council on Harmonization) guidelines and compiled with the required criteria and standards. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
