التفاصيل البيبلوغرافية
| العنوان: |
Skeletal Muscle Mass Index Reduction Rate as a Prognostic Indicator for Patients Undergoing Pancreatectomy for Pancreatic Cancer. |
| المؤلفون: |
JUNYA MITA, TAKASHI MAEDA, EIJI TSUJITA, NAOTAKA HASHIMOTO, RANMA FUJIKAWA, YUKI ONO, AKIHIRO SAKAI, SHINICHI TANAKA, RUMI MATONO, TAKAHIRO OHMINE, TAKURO KOMETANI, SHOHEI YAMAGUCHI, KOZO KONISHI, KENKICHI HASHIMOTO |
| المصدر: |
Cancer Diagnosis & Prognosis; May/Jun2024, Vol. 4 Issue 3, p301-308, 8p |
| مصطلحات موضوعية: |
PANCREATECTOMY, SKELETAL muscle, MUSCLE mass, PANCREATIC cancer, PANCREATIC surgery, RECEIVER operating characteristic curves |
| مستخلص: |
Background/Aim: There have been many studies on skeletal muscle depletion before surgery, and skeletal muscle depletion is a known risk factor for poor prognosis. However, reports on the association between changes in skeletal muscle mass and prognosis after surgery for pancreatic cancer are very few. Patients and Methods: The data of 137 patients who underwent pancreatectomy for pancreatic cancer between 2005 and 2022 were reviewed. Muscle areas were measured at the third lumbar vertebral level, and skeletal muscle mass index (SMI) reduction rates were calculated. Patients were divided into two groups using receiver operating characteristic (ROC) curve analysis based on the SMI reduction rate with a cutoff of 14% reduction rate. The clinicopathological factors, overall survival (OS), and recurrence-free survival (RFS) were compared between the two groups. Survival rates were analyzed both univariately and multivariately to clarify the factors associated with poor prognosis after pancreatectomy. Results: A total of 102 patients met the inclusion criteria. SMI reduction rate ≥14% significantly correlated with advanced age and higher incidence of postoperative complications. In the multivariate Cox regression analysis, preoperative prognostic nutritional index (PNI) <40 and SMI reduction rate ≥14% were significantly associated with poor OS. Tumor size =3.0 cm, preoperative neutrophilelymphocyte ratio =3.0, and SMI reduction rate ≥14% were significantly associated with poor RFS. Conclusion: The rate of skeletal muscle mass reduction after pancreatic surgery is an independent prognostic factor for survival in patients with pancreatic cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
