التفاصيل البيبلوغرافية
| العنوان: |
Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA). |
| المؤلفون: |
Overbey, Eliah G., Ryon, Krista, Kim, JangKeun, Tierney, Braden T., Klotz, Remi, Ortiz, Veronica, Mullane, Sean, Schmidt, Julian C., MacKay, Matthew, Damle, Namita, Najjar, Deena, Matei, Irina, Patras, Laura, Garcia Medina, J. Sebastian, Kleinman, Ashley S., Wain Hirschberg, Jeremy, Proszynski, Jacqueline, Narayanan, S. Anand, Schmidt, Caleb M., Afshin, Evan E. |
| المصدر: |
Nature Communications; 6/11/2024, Vol. 15 Issue 1, p1-14, 14p |
| مصطلحات موضوعية: |
SPACE biology, MONONUCLEAR leukocytes, HUMAN space flight, VESICLES (Cytology), HEPA filters, SALIVA, HUMAN body |
| مستخلص: |
The SpaceX Inspiration4 mission provided a unique opportunity to study the impact of spaceflight on the human body. Biospecimen samples were collected from four crew members longitudinally before (Launch: L-92, L-44, L-3 days), during (Flight Day: FD1, FD2, FD3), and after (Return: R + 1, R + 45, R + 82, R + 194 days) spaceflight, spanning a total of 289 days across 2021-2022. The collection process included venous whole blood, capillary dried blood spot cards, saliva, urine, stool, body swabs, capsule swabs, SpaceX Dragon capsule HEPA filter, and skin biopsies. Venous whole blood was further processed to obtain aliquots of serum, plasma, extracellular vesicles and particles, and peripheral blood mononuclear cells. In total, 2,911 sample aliquots were shipped to our central lab at Weill Cornell Medicine for downstream assays and biobanking. This paper provides an overview of the extensive biospecimen collection and highlights their processing procedures and long-term biobanking techniques, facilitating future molecular tests and evaluations.As such, this study details a robust framework for obtaining and preserving high-quality human, microbial, and environmental samples for aerospace medicine in the Space Omics and Medical Atlas (SOMA) initiative, which can aid future human spaceflight and space biology experiments. Here the authors provide the biospecimen collection methodology from the SpaceX Inspiration4 mission, including venous blood, capillary blood, saliva, urine, stool, skin biopsy, body swab, and environmental swab samples. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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