التفاصيل البيبلوغرافية
| العنوان: |
纤维蛋白原对2 型糖尿病患者冠状动脉斑块狭窄率进展的影响. (Chinese) |
| Alternate Title: |
Effect of fibrinogen on the progression of coronary plaque stenosis rate in patients with type 2 diabetes mellitus. (English) |
| المؤلفون: |
荐志洁, 乔香瑞, 李海波, 姚果林, 郭华峰, 刘辉, 吴岳, 杨健, 成乐乐 |
| المصدر: |
Chinese Journal of Arteriosclerosis; May2024, Vol. 32 Issue 5, p410-414, 5p |
| Abstract (English): |
Aim To investigate the relationship between fibrinogen (FIB) and the progression of coronary plaque stenosis rate in patients with type 2 diabetes mellitus (T2DM). Methods Hospitalized T2DM patients who underwent two or more coronary CT angiography (CCTA) examinations in the First Affiliated Hospital of Xian Jiaotong University from January 2015 to December 2020 were included. The subjects were divided into high FIB and low FIB groups according to the median of FIB. The differences in the progression of coronary plaque stenosis rate and other clinical characteristics were compared between the two groups, and the relationship between FIB level and the progression of coronary plaque stenosis rate was analyzed by Spearmans correlation analysis and Logistic regression. Results A total of 145 patients were included, 73 in the high FIB group and 72 in the low FIB group at baseline, with a median follow-up time of 25 (18, 40) months between CCTA. The age, proportion of women, and the progression of coronary plaque stenosis rate were higher in the high FIB group than those in the low FIB group, and the differences were statistically significant (P<0. 05). FIB level was positively correlated with the change in coronary plaque stenosis rate (r2 = 0. 308, P< 0. 001). Multivariate Logistic regression analysis showed that FIB level was a risk factor for the progression of coronary plaque stenosis rate in patients with T2DM (OR=5. 25, 95%CI: 1. 97 ~14. 02, P<0. 001), after adjusting for age, sex and other clinical risk factors. Conclusion High baseline FIB level is an independent risk factor for the progression of coronary plaque stenosis rate in patients with T2DM, and monitoring FIB level is beneficial to cardiovascular risk stratification in patients with T2DM. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
[目的] 探讨纤维蛋白原(FIB) 与2 型糖尿病(T2DM) 患者冠状动脉斑块狭窄率进展的关系。[ 方 法] 纳入2015 年1 月─2020 年12 月在西安交通大学第一附属医院行两次及以上冠状动脉CT 血管成像(CCTA) 检查的T2DM 住院患者,根据FIB 中位数将受试者分为高FIB 组和低FIB 组。比较高、低FIB 两组间冠状动脉斑块 狭窄率进展及其他临床特征的差异,采用Spearman 相关性分析和Logistic 回归分析FIB 水平与冠状动脉斑块狭窄 率进展的关系。[结果] 共纳入患者145 例,高FIB 组73 例,低FIB 组72 例,两次CCTA 中位随访时间为25(18, 40)个月。高FIB 组年龄、女性比例及斑块狭窄率进展高于低FIB 组,差异均有统计学意义(P<0. 05)。FIB 水平与 斑块狭窄率变化呈正相关(r2 =0. 308,P<0. 001)。多元Logistic 回归分析显示,在校正年龄、性别及其他多种临床 指标后,FIB 水平为T2DM 患者冠状动脉斑块狭窄率进展的危险因素(OR=5. 25,95% CI:1. 97 ~ 14. 02,P<0. 001)。 [结论] 基线高FIB 水平是T2DM 患者冠状动脉斑块狭窄率进展的独立危险因素,监测FIB 水平有利于T2DM 患 者的心血管危险分层。 [ABSTRACT FROM AUTHOR] |
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