التفاصيل البيبلوغرافية
| العنوان: |
Polyvalent Bacterial Lysate with Potential Use to Treatment and Control of Recurrent Urinary Tract Infections. |
| المؤلفون: |
Acevedo-Monroy, Salvador Eduardo, Rocha-Ramírez, Luz María, Martínez Gómez, Daniel, Basurto-Alcántara, Francisco Javier, Medina-Contreras, Óscar, Hernández-Chiñas, Ulises, Quiñones-Peña, María Alejandra, García-Sosa, Daniela Itzel, Ramírez-Lezama, José, Rodríguez-García, José Alejandro, González-Villalobos, Edgar, Castro-Luna, Raúl, Martínez-Cristóbal, Leonel, Eslava-Campos, Carlos Alberto |
| المصدر: |
International Journal of Molecular Sciences; Jun2024, Vol. 25 Issue 11, p6157, 19p |
| مصطلحات موضوعية: |
URINARY tract infections, CITROBACTER freundii, ANIMAL culture, ETIOLOGY of diseases, KLEBSIELLA pneumoniae |
| مستخلص: |
Overuse of antimicrobials has greatly contributed to the increase in the emergence of multidrug-resistant bacteria, a situation that hinders the control and treatment of infectious diseases. This is the case with urinary tract infections (UTIs), which represent a substantial percentage of worldwide public health problems, thus the need to look for alternatives for their control and treatment. Previous studies have shown the usefulness of autologous bacterial lysates as an alternative for the treatment and control of UTIs. However, a limitation is the high cost of producing individual immunogens. At the same time, an important aspect of vaccines is their immunogenic amplitude, which is the reason why they must be constituted of diverse antigenic components. In the case of UTIs, the etiology of the disease is associated with different bacteria, and even Escherichia coli, the main causal agent of the disease, is made up of several antigenic variants. In this work, we present results on the study of a bacterial lysate composed of 10 serotypes of Escherichia coli and by Klebsiella pneumoniae, Klebsiella aerogenes, Enterococcus faecalis, Proteus mirabilis, Citrobacter freundii, and Staphylococcus haemolyticus. The safety of the compound was tested on cells in culture and in an animal model, and its immunogenic capacity by analysing in vitro human and murine macrophages (cell line J774 A1). The results show that the polyvalent lysate did not cause damage to the cells in culture or alterations in the animal model used. The immunostimulatory activity assay showed that it activates the secretion of TNF-α and IL-6 in human macrophages and TNF-α in murine cells. The obtained results suggest that the polyvalent lysate evaluated can be an alternative for the treatment and control of chronic urinary tract infections, which will reduce the use of antimicrobials. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder