التفاصيل البيبلوغرافية
| العنوان: |
Serum Soluble IL-2 Receptors Are Elevated in Febrile Illnesses and Useful for Differentiating Clinically Similar Malignant Lymphomas from Kikuchi Disease: A Cross-Sectional Study. |
| المؤلفون: |
Fuwa, Masayuki, Tamai, Yuya, Kato, Ayaka, Asano, Motochika, Mori, Ichiro, Watanabe, Daichi, Morita, Hiroyuki |
| المصدر: |
Journal of Clinical Medicine; Jun2024, Vol. 13 Issue 11, p3248, 10p |
| مصطلحات موضوعية: |
INTERLEUKIN receptors, CROSS-sectional method, HEMOPHAGOCYTIC lymphohistiocytosis, LYMPHOMAS, ETIOLOGY of diseases |
| مستخلص: |
Background: The use of serum soluble interleukin 2 receptor (sIL-2R) for the diagnosis of febrile illnesses has not been examined. In this study, febrile patients were classified according to etiology and disease, and serum sIL-2R levels were evaluated. We determined whether serum sIL-2R is a useful marker for differentiating between malignant lymphoma (ML) and non-ML patients and between patients with ML and Kikuchi disease, which present similar clinical manifestations. Methods: This study was a cross-sectional study and included 344 patients with uncomplicated hemophagocytic syndrome, who had a fever of 38 °C or higher within 1 week of admission to our institution. Patient serum sIL-2R was measured, and the serum sIL-2R values are shown as median and IQR. Results: Serum sIL-2R increased above the upper reference limit in all disease groups with fever. The serum sIL-2R level in ML patients (n = 13) was 4760 (2120–6730) U/mL and significantly higher (p < 0.001) than the level of 998 (640–1625) U/mL in non-ML patients (n = 331). The serum sIL-2R level in ML patients (n = 13) was also significantly higher (p < 0.001) compared with that in patients with Kikuchi disease (n = 20; 705 (538–1091) U/mL). Conclusions: Serum sIL-2R tends to exceed the upper reference limit in patients with febrile illnesses. We conclude that the measurement of serum sIL-2R is useful for differentiating ML from non-ML and ML from Kikuchi disease. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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